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NGS Leaders Blog

Global Competition to Inspire Breakthrough Innovation and Technologies

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Editor’s Note: In the following guest blog post, X-Prize Foundation's Grant Campany provides an overview of the Archon Genomics X PRIZE whole genome sequencing competition. For more information visit: http://genomics.xprize.org/  

April 9, 2012 : Grant R. Campany (Senior Director & Prize Lead, Archon Genomics X PRIZE, X-Prize Foundation) : One of the most fascinating aspects of the Archon Genomics X PRIZE presented by Medco®, is the validation protocol we designed to declare the $10 million winner of our Competition.  Our scientific advisors are collaborating with agencies nationally and internationally to establish our protocol as a global, consensus-driven “standard” for whole human genome sequencing, once the Competition ends. Our efforts so far have earned support from the FDA, NIH and NIA. http://www.youtube.com/watch?v=oWC1knVaQHI. 

To those of you unfamiliar with the Archon Genomics X PRIZE presented by Medco, it is an incentivized prize competition that will award $10 million to the first WGS Team to submit 100 human genome sequences in 30 days or less at a maximum cost of $1K per genome, at an accuracy score of no more than one error per 1,000,000 bases, present each genome as 98% complete, and provide accurate haplotype phasing. 

If those thresholds are met or exceeded, it will define for the first time, what it means to have a complete and accurate “medical grade" whole human genome sequence.  

Since each WGS Team is required to sequence the same set of 100 genomes, we thought long and hard to identify a disease set that would benefit most from the data our Competition will produce. It was suggested that instead of selecting a disease, to find the healthiest and long lived among us to sequence.  All 100 genomes will be donated by 100 centenarians (ages 100 or older) from all over the world, and will be known as the Medco 100 Over 100. Sequencing the genomes of the Medco 100 Over 100 presents an unprecedented opportunity to identify those "rare genes" that protect against diseases, while giving researchers valuable clues to health and longevity.  

The result will be the world's first "medical grade” centenarian genome, a critically-needed clinical standard that will transform genomic research into usable medical information to improve patient diagnosis and treatment.  

The goal of this global competition is to inspire breakthrough genome sequencing innovations and technologies that will usher in a new era of personalized medicine. 

I-Study: Genomic Interpretation - Who Will Pay?
During this webinar, members of the study review team present preliminary findings of the I-Study, conducted at the Harvard Medical School's 2011 Personalized Medicine Conference.
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